A digital meter provides accurate values of command signals and membrane currents or voltages, the true RMS noise of the amplifier and experimental setup, the cut off frequency of the low pass filter, and the overall gain of the amplifier plus probe. For signals that are more complicated, an external command input with different scaling factors is available for use with any signal source. Calibrated whole cell compensation provide easy display of membrane capacitance and access resistance.Ī host of command potentials are integrated internally within the model 2400, including an automatic tracking command to zero the membrane current, manual controls for offset and holding potentials, and an easily readable digital display. Fine tuning capacity compensation is available to eliminate virtually all electrode-induced transients. An integrated four pole low pass Bessel filter provides flexible signal conditioning. ![]() This allows this amplifier to be a true fast current clamp amplifier with no instability. Unlike other patch clamp amplifiers, the Model 2400 has a voltage follower in the probe. The standard probe sent with each unit is the 100 M>Ω/10 G>Ω version, but other values can be selected. The wide range of feedback resistors means currents can be recorded with outputs of 1 mV/nA to 10 mV/fA. There are three heastages to choose from: 1 GΩ/10 MΩ, 10 GΩ/10 MΩ, and 10 GΩ/100 MΩ. Test-Drive the New Isolated High-Power StimulatorĪmplifier current gain can be matched to your experimental needs by selecting one of the three available dual resistive feedback probes, as the gain is partially determined by the value of the resistor in the headstage.
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